Interleukin-6 (IL-6) is a pro-inflammatory cytokine that plays important roles in the acute immune reaction phase, inflammation and cancer progression among others. Mature human IL-6 has a molecular weight of 21kDa. IL-6 is secreted by T cells and is important for antibody production by B cells. Elevated tissue and serum levels of IL-6 have been implicated in the etiology of several inflammatory and autoimmune disorders, including cytokine storm and more recently COVID-19 acute respiratory distress syndrome. Antibodies against IL-6 (Siltuximab) or its receptor IL-6R (Tocilizumab, Sarilumab) are clinically proven to alleviate IL-6 deleterious effects.
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