Astrea Bioseparations_Chromatography Resins
Astrea Bioseparations_Chromatography Resins

AlbuPure® for Purification of Albumin Fusion Proteins

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What is an Albumin Fusion Protein?

Albumin fusion protein technology is becoming an important tool for the delivery of therapeutic peptides and proteins. In the Albumin fusion protein, Albumin is genetically fused with a therapeutic partner resulting in a contiguous protein that has an extended circulatory half-life while retaining therapeutic activity.

What is the function of an Albumin Fusion Protein?

The fused Albumin-drug compound can assist with the drug’s delivery and extend the half-life of a protein drug as a fusion partner, whilst maintaining its activity. In order to support the rising production of a wide range of recombinant albumin fusion proteins, an affinity matrix has been developed that is highly stable, robust, non-toxic and provides high binding capacity, recovery and purity: AlbuPure®.


Developed in partnership with Albumedix and manufactured exclusively by Astrea Bioseparations Ltd (Astrea), is a high-performance affinity chromatography adsorbent that is highly stable, robust and non-toxic providing high binding capacity, recovery and selectivity for albumin fusion proteins.

AlbuPure® combined with Albumedix’ Veltis® expression technology provides a complete albumin fusion purification package, available in a variety of formats to suit application and scale required.

Find out more about Albumedix’ Veltis® expression technology. 

Key features of AlbuPure®:

  • Suitable for a wide range of recombinant albumin fusion proteins
  • Novel synthetic triazine ligand
  • Excellent flow properties
  • High dynamic binding capacity
  • Robust and long life adsorbent
  • Sanitizable using Sodium Hydroxide
  • Colourless ligand
  • Easy to pack
  • Manufactured to ISO9001 accredited standard
  • Single batches produced of up to 275 litres
  • Supported with a comprehensive Regulatory Support File (includes leachables and extractables)


AlbuPure® is a selective affinity chromatography adsorbent developed by Astrea Bioseparations Ltd (Astrea) in collaboration with Albumedix for the purification of albumin-fusion proteins.

AlbuPure® is manufactured exclusively by Astrea in a controlled environment to ISO 9001 quality standard and is produced and designed for use in cGMP manufacturing of biological molecules.

The AlbuPure® adsorbent comprises a novel synthetic triazine ligand derived from Astrea’s Mimetic Ligand™ technology and is coupled to Astrea’s proprietary PuraBead® 6HF base matrix (a highly cross-linked 6% near monodisperse beaded agarose). This proven technology provides a stable ligand and attachment chemistry with low ligand leakage that enables the use of up to 1.0 M NaOH for cleaning and sanitization ensuring extended adsorbent lifetimes.

Additional information


Sythetic triazine

Absorbent appearance


Base Matrix

Highly cross-linked 6% near monodisperse agarose (PuraBead 6HF)

Particle Size

90 ± 10µm

Binding Capacity

> 35 g/L*

Packing Conditions

Saline solution at a constant pressure of 2.5 bar (~22 psi)

Operational flow rate

Up to 600 cm/hr

Chemical Stability

Stable in all commonly used buffers and solutions


0.5 to 1.0M NaOH


2-8◦C, 20% Ethanol, 0.1M NaCl


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25 mL

100 mL

500 mL

1000 mL