Serum albumin is the most abundant blood plasma protein and is produced in the liver. In human plasma, human serum albumin normally constitutes about 50% of the total protein.
Serum albumins are important in regulating blood volume by maintaining the oncotic pressure (also known as colloid osmotic pressure) of the blood compartment. They also serve as carriers for molecules of low water solubility, this way isolating their hydrophobic nature, including lipid-soluble hormones, bile salts, unconjugated bilirubin, free fatty acids (apoprotein), calcium, ions (transferrin), and some drugs like warfarin, phenobutazone, clofibrate & phenytoin. For this reason, it is sometimes referred as a molecular “taxi”. Competition between drugs for albumin binding sites may cause drug interaction by increasing the free fraction of one of the drugs, thereby affecting potency.
Astrea Bioseparations’ range of Mimetic Blue® affinity adsorbents comprise Mimetic Blue® ligands attached to beaded agarose supports, which selectively bind to Albumin and Albumin related proteins from a variety of sources, including plasma, serum and recombinant cell cultures to yield highly purified biological products.
The adsorbents are used commercially for the purification of albumin and albumin related proteins (i.e. albumin fusion proteins) but also are applicable to a variety of other proteins including adenine nucleotide binding proteins.
Mimetic Blue SA HL P6XL
Mimetic Blue SA P6XL
Mimetic Blue SA P6HF